Charles River Laboratories International, Inc. (CRL)

業務介紹

查爾斯河實驗室國際公司是一家非臨床合同研究組織,在美國、歐洲、加拿大、亞太地區和國際上提供藥物發現、非臨床開發和安全性測試服務。它通過三個部門運營:研究模型和服務(RMS)、發現和安全評估(DSA)以及製造解決方案(製造)。

RMS部門生產和銷售啮齒類研究模型品系,以及供研究人員使用的目的培育大鼠和小鼠。該部門還提供一系列服務,以協助客戶支持在研究和篩選非臨床藥物候選物中使用研究模型,包括研究模型、基因工程模型和服務、內部外包解決方案以及研究動物診斷服務。

DSA部門提供早期和體內發現服務,用於識別和驗證新的靶標、化合物和抗體,並提供準備好進行安全性評估的非臨床藥物和治療候選物;以及毒理學、病理學、安全性藥理學、生物分析、藥物代謝和藥代動力學等安全性評估服務。

製造部門提供常規和快速質量控制測試的體外方法,用於無菌和非無菌的藥品和消費品。該部門還提供生物製品的專門測試,這些測試是由製藥和生物技術公司外包的;以及提供用於製造疫苗的特定病原體自由(SPF)肥沃雞蛋、SPF雞和診斷產品的禽用疫苗服務。

該公司還為生物製藥客戶提供合同動物房運營服務。查爾斯河實驗室國際公司成立於1947年,總部位於馬薩諸塞州的威明頓。



Charles River Laboratories International, Inc., a non-clinical contract research organization, provides drug discovery, non-clinical development, and safety testing services in the United States, Europe, Canada, the Asia Pacific, and internationally. It operates through three segments: Research Models and Services (RMS), Discovery and Safety Assessment (DSA), and Manufacturing Solutions (Manufacturing). The RMS segment produces and sells rodent research model strains and purpose-bred rats and mice for use by researchers. This segment also provides a range of services to assist its clients in supporting the use of research models in research and screening non-clinical drug candidates, including research models, genetically engineered models and services, insourcing solutions, and research animal diagnostic services. The DSA segment offers early and in vivo discovery services for the identification and validation of novel targets, chemical compounds, and antibodies through delivery of non-clinical drug and therapeutic candidates ready for safety assessment; and safety assessment services, such as toxicology, pathology, safety pharmacology, bioanalysis, drug metabolism, and pharmacokinetics services. The Manufacturing segment provides in vitro methods for conventional and rapid quality control testing of sterile and non-sterile pharmaceuticals and consumer products. This segment also offers specialized testing of biologics that are outsourced by pharmaceutical and biotechnology companies; and avian vaccine services that provide specific-pathogen-free (SPF) fertile chicken eggs, SPF chickens, and diagnostic products used to manufacture vaccines. The company also provides contract vivarium operation services to biopharmaceutical clients. Charles River Laboratories International, Inc. was founded in 1947 and is headquartered in Wilmington, Massachusetts.

公司網址

https://www.criver.com